| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 2 |
|---|
| Ligand | BDBM14245 |
|---|
| Substrate/Competitor | BDBM13466 |
|---|
| Meas. Tech. | Enzymatic Assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| Ki | 320±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Wan, ZK; Lee, J; Xu, W; Erbe, DV; Joseph-McCarthy, D; Follows, BC; Zhang, YL Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48. Bioorg Med Chem Lett16:4941-5 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Tyrosine-protein phosphatase non-receptor type 2 |
|---|
| Name: | Tyrosine-protein phosphatase non-receptor type 2 |
|---|
| Synonyms: | PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 48481.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P17706 |
|---|
| Residue: | 415 |
|---|
| Sequence: | MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
|
|
|
|---|
| BDBM14245 |
|---|
| BDBM13466 |
|---|
| Name | BDBM14245 |
|---|
| Synonyms: | 4-bromo-3-(carboxymethoxy)-5-phenylthiophene-2-carboxylic acid | CHEMBL213758 | Monocyclic thiophene analog 11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H9BrO5S |
|---|
| Mol. Mass. | 357.177 |
|---|
| SMILES | OC(=O)COc1c(Br)c(sc1C(O)=O)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
