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TargetTryptophan 5-hydroxylase 1
LigandBDBM341387
Substrate/Competitorn/a
Meas. Tech.Biochemical In Vitro Assay
IC50 4.00±n/a nM
Citation Bur, DGrisostomi, CNayler, ORemen, LVercauteren, MWelford, R Tricyclic piperidine compounds US Patent US9765092 Publication Date 9/19/2017
More Info.:Get all data from this article,  Assay Method
 
Tryptophan 5-hydroxylase 1
Name:Tryptophan 5-hydroxylase 1
Synonyms:TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:PROTEIN
Mol. Mass.:50990.64
Organism:Homo sapiens (Human)
Description:ChEMBL_1361824
Residue:444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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  Blast E-value cutoff:
BDBM341387
n/a
NameBDBM341387
Synonyms:1-(5-(4-cyclopropyl-2-fluorophenyl)-2-methyl-7,8-dihydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-((2-(trifluoromethyl)pyridin-3-yl)oxy)ethanone | US9765092, Example 1.6.13
TypeSmall organic molecule
Emp. Form.C25H21F4N5O2S
Mol. Mass.531.525
SMILESCc1nn2c3C(N(CCc3nc2s1)C(=O)COc1cccnc1C(F)(F)F)c1ccc(cc1F)C1CC1
Structure
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