Reaction Details |
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Target | Tryptophan 5-hydroxylase 1 |
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Ligand | BDBM341524 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical In Vitro Assay |
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IC50 | 4.00±n/a nM |
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Citation | Bur, D; Grisostomi, C; Nayler, O; Remen, L; Vercauteren, M; Welford, R Tricyclic piperidine compounds US Patent US9765092 Publication Date 9/19/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Tryptophan 5-hydroxylase 1 |
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Name: | Tryptophan 5-hydroxylase 1 |
Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
Type: | PROTEIN |
Mol. Mass.: | 50990.64 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1361824 |
Residue: | 444 |
Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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BDBM341524 |
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n/a |
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Name | BDBM341524 |
Synonyms: | 1-(5-(5-chloro-3-fluoropyridin-2-yl)-2-methyl-7,8-dihydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-((2-chloro-6-(3,3-difluoroazetidin-1-yl)pyridin-3-yl)oxy)ethanone | US9765092, Example 1.33.2 |
Type | Small organic molecule |
Emp. Form. | C23H18Cl2F3N7O2S |
Mol. Mass. | 584.401 |
SMILES | Cc1nn2c3C(N(CCc3nc2s1)C(=O)COc1ccc(nc1Cl)N1CC(F)(F)C1)c1ncc(Cl)cc1F |
Structure |
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