| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 5-hydroxylase 1 |
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| Ligand | BDBM341569 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical In Vitro Assay |
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| IC50 | 5.00±n/a nM |
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| Citation |  Bur, D; Grisostomi, C; Nayler, O; Remen, L; Vercauteren, M; Welford, R Tricyclic piperidine compounds US Patent US9765092 Publication Date 9/19/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 5-hydroxylase 1 |
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| Name: | Tryptophan 5-hydroxylase 1 |
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| Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50990.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1361824 |
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| Residue: | 444 |
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| Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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| BDBM341569 |
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| n/a |
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| Name | BDBM341569 |
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| Synonyms: | 2-((2-chloro-6-(1,1-dioxidoisothiazolidin-2-yl)pyridin-3-yl)oxy)-1-(5-(2,4-dimethylthiazol-5-yl)-2-methyl-7,8-dihydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)ethanone | US9765092, Example 1.68.5 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24ClN7O4S3 |
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| Mol. Mass. | 594.129 |
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| SMILES | Cc1nc(C)c(s1)C1N(CCc2nc3sc(C)nn3c12)C(=O)COc1ccc(nc1Cl)N1CCCS1(=O)=O |
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| Structure | 
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