| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tryptophan 5-hydroxylase 1 |
|---|
| Ligand | BDBM341632 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical In Vitro Assay |
|---|
| IC50 | 4.00±n/a nM |
|---|
| Citation |  Bur, D; Grisostomi, C; Nayler, O; Remen, L; Vercauteren, M; Welford, R Tricyclic piperidine compounds US Patent US9765092 Publication Date 9/19/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tryptophan 5-hydroxylase 1 |
|---|
| Name: | Tryptophan 5-hydroxylase 1 |
|---|
| Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50990.64 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1361824 |
|---|
| Residue: | 444 |
|---|
| Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
|
|
|
|---|
| BDBM341632 |
|---|
| n/a |
|---|
| Name | BDBM341632 |
|---|
| Synonyms: | 1-((5R)-5-(4-chloro-2-fluorophenyl)-4a,5-dihydro-thiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(7H)-yl)-2-(2-chloro-4-morpholinophenoxy)ethanone | US9765092, Example 6.4.2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H23Cl2FN4O3S |
|---|
| Mol. Mass. | 561.455 |
|---|
| SMILES | Fc1cc(Cl)ccc1[C@@H]1C2N3C=CSC3=NC2=CCN1C(=O)COc1ccc(cc1Cl)N1CCOCC1 |c:12,16,19| |
|---|
| Structure | 
|
|---|
Search and Browse
