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TargetTryptophan 5-hydroxylase 1
LigandBDBM341710
Substrate/Competitorn/a
Meas. Tech.Biochemical In Vitro Assay
IC50 3.00±n/a nM
Citation Bur, DGrisostomi, CNayler, ORemen, LVercauteren, MWelford, R Tricyclic piperidine compounds US Patent US9765092 Publication Date 9/19/2017
More Info.:Get all data from this article,  Assay Method
 
Tryptophan 5-hydroxylase 1
Name:Tryptophan 5-hydroxylase 1
Synonyms:TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:PROTEIN
Mol. Mass.:50990.64
Organism:Homo sapiens (Human)
Description:ChEMBL_1361824
Residue:444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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BDBM341710
n/a
NameBDBM341710
Synonyms:1-(5-(4-Chloro-2-fluorophenyl)-2-methyl-7,8-dihydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-((2-chloro-6-((2-methoxyethyl)(methyl)-amino)pyridin-3-yl)oxy)ethanone | US9765092, Example 1.4.14
TypeSmall organic molecule
Emp. Form.C25H25Cl2FN6O3S
Mol. Mass.579.474
SMILESCOCCN(C)c1ccc(OCC(=O)N2CCc3nc4sc(C)nn4c3C2c2ccc(Cl)cc2F)c(Cl)n1
Structure
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