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TargetRibosomal protein S6 kinase alpha 2
LigandBDBM342167
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
IC50 23000±n/a nM
Citation Dunn SEJayanthan ANagireddy JRAnnedi SVan Drie JHDaynard TSHuynh M Substituted tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamides as RSK inhibitors US Patent  US9771366 Publication Date 9/26/2017
More Info.:Get all data from this article,  Assay Method
 
Ribosomal protein S6 kinase alpha 2
Name:Ribosomal protein S6 kinase alpha 2
Synonyms:90 kDa ribosomal protein S6 kinase 2 | 90 kDa ribosomal protein S6 kinase 2 (RSK2) | MAP kinase-activated protein kinase 1c | MAPKAPK1C | RPS6KA2(Kin.Dom.1 - N-terminal) | Ribosomal S6 Kinase 3 (RSK-3) | Ribosomal protein S6 kinase alpha-2 | p90-RSK 2 | pp90RSK3
Type:Serine/threonine-protein kinase
Mol. Mass.:83259.46
Organism:Homo sapiens (Human)
Description:n/a
Residue:733
Sequence:
MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFE
LLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPF
IVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGI
IYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA
DWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCN
RLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDS
PGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKED
IGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGK
FVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILY
RDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGIL
LYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQR
LTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLA
QRRGMKRLTSTRL
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  Blast E-value cutoff:
BDBM342167
n/a
NameBDBM342167
Synonyms:(R)-N-(1-(3-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl-6-oxo-6,7,8,9-tetrahydropyrido[3',2':4,5]pyrrolo[1,2-a]pyrazine-2-carboxamide | US9771366, Compound 16
TypeSmall organic molecule
Emp. Form.C22H21N7O2
Mol. Mass.415.4478
SMILESC[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2cccc(N)c2)c1 |r|
Structure
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