Reaction Details |
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Target | Mast/stem cell growth factor receptor Kit [D816V] |
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Ligand | BDBM342169 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Biochemical Assay |
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Ki | 500±n/a nM |
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Citation | Lin, J; Pham, P; Buell, J; Spevak, W Compounds and methods for kinase modulation, and indications therefor US Patent US9771369 Publication Date 9/26/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Mast/stem cell growth factor receptor Kit [D816V] |
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Name: | Mast/stem cell growth factor receptor Kit [D816V] |
Synonyms: | KIT | KIT_HUMAN | Mast/stem cell growth factor receptor Kit (D816V) | Mast/stem cell growth factor receptor Kit 1 (D816V) | SCFR | Tyrosine-protein kinase Kit (Kit)(D816V) |
Type: | Protein |
Mol. Mass.: | 109854.42 |
Organism: | Homo sapiens (Human) |
Description: | Human Kit D816V mutant |
Residue: | 976 |
Sequence: | MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARVIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVHDDV
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BDBM342169 |
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n/a |
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Name | BDBM342169 |
Synonyms: | 6-(4-fluorophenyl)-4-[4-[4-methyl-5-[3- (trifluoromethoxy)phenyl]-1H-imidazol- 2-yl]-1-piperidyl]-7H-pyrrolo[2,3- d]pyrimidine | US9771369, Compound P-3011 |
Type | Small organic molecule |
Emp. Form. | C28H24F4N6O |
Mol. Mass. | 536.5234 |
SMILES | Cc1nc([nH]c1-c1cccc(OC(F)(F)F)c1)C1CCN(CC1)c1ncnc2[nH]c(cc12)-c1ccc(F)cc1 |
Structure |
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