| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mast/stem cell growth factor receptor Kit |
|---|
| Ligand | BDBM342343 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biochemical Assay |
|---|
| Ki | 500±n/a nM |
|---|
| Citation |  Lin, J; Pham, P; Buell, J; Spevak, W Compounds and methods for kinase modulation, and indications therefor US Patent US9771369 Publication Date 9/26/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mast/stem cell growth factor receptor Kit |
|---|
| Name: | Mast/stem cell growth factor receptor Kit |
|---|
| Synonyms: | CD117 antigen | CD_antigen=CD117 | KIT | KIT_HUMAN | Mast/stem cell growth factor receptor Kit (cKIT) | Proto-oncogene c-Kit | Proto-oncogene tyrosine-protein kinase Kit | SCFR | Stem cell growth factor receptor | Tyrosine Kinase c-Kit | Tyrosine-protein kinase Kit | Tyrosine-protein kinase Kit (c-Kit) | c-kit | p-145 c-kit | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 109869.37 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P10721 |
|---|
| Residue: | 976 |
|---|
| Sequence: | MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVHDDV
|
|
|
|---|
| BDBM342343 |
|---|
| n/a |
|---|
| Name | BDBM342343 |
|---|
| Synonyms: | 4-[4-[5-(4-chlorophenyl)-4-methyl-1H- imidazol-2-yl]-4-methyl-1-piperidyl]-6- [1-(difluoromethyl)pyrazol-4-yl]-7H- pyrrolo[2,3-d]pyrimidine | US9771369, Compound P-3175 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H25ClF2N8 |
|---|
| Mol. Mass. | 522.98 |
|---|
| SMILES | Cc1nc([nH]c1-c1ccc(Cl)cc1)C1(C)CCN(CC1)c1ncnc2[nH]c(cc12)-c1cnn(c1)C(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
