| Reaction Details |
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 | Report a problem with these data |
| Target | Ketohexokinase |
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| Ligand | BDBM50349744 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | 90.0±n/a nM |
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| Citation |  Zhang, X; Abad, MC; Gibbs, AC; Kuo, G; Song, F; Sui, Z; Kuo, LC Indazole compounds useful as ketohexokinase inhibitors US Patent US9771375 Publication Date 9/26/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ketohexokinase |
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| Name: | Ketohexokinase |
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| Synonyms: | Hepatic fructokinase | KHK | KHK_HUMAN | Ketohexokinase | Ketohexokinase (KHK) | Ketohexokinase (KHK) Isoform C |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 32521.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 298 |
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| Sequence: | MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
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| BDBM50349744 |
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| n/a |
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| Name | BDBM50349744 |
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| Synonyms: | CHEMBL1809171 | US8822447, 140 | US9771375, Example 140 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N3OS |
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| Mol. Mass. | 351.465 |
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| SMILES | COc1ccc(cc1)-n1nc(SC)c2ccc(cc12)C1=CCNCC1 |t:22| |
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| Structure | 
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