| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ketohexokinase |
|---|
| Ligand | BDBM8526 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assay |
|---|
| IC50 | 40.0±n/a nM |
|---|
| Citation |  Zhang, X; Abad, MC; Gibbs, AC; Kuo, G; Song, F; Sui, Z; Kuo, LC Indazole compounds useful as ketohexokinase inhibitors US Patent US9771375 Publication Date 9/26/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ketohexokinase |
|---|
| Name: | Ketohexokinase |
|---|
| Synonyms: | Hepatic fructokinase | KHK | KHK_HUMAN | Ketohexokinase | Ketohexokinase (KHK) | Ketohexokinase (KHK) Isoform C |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 32521.64 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 298 |
|---|
| Sequence: | MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFM
GSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDV
SATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELF
QLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLL
HSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
|
|
|
|---|
| BDBM8526 |
|---|
| n/a |
|---|
| Name | BDBM8526 |
|---|
| Synonyms: | CHEMBL1809170 | US8822447, 107 | US8822448, 184 | US9771375, Example 184 |
|---|
| Type | n/a |
|---|
| Emp. Form. | C20H21N3S |
|---|
| Mol. Mass. | 335.466 |
|---|
| SMILES | CSc1nn(-c2ccc(C)cc2)c2cc(ccc12)C1=CCNCC1 |t:21| |
|---|
| Structure | 
|
|---|
Search and Browse
