Reaction Details | |||
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Target | Sodium channel protein type 9 subunit alpha | ||
Ligand | BDBM342434 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Electrophysiological Assay (In Vitro Assay) | ||
IC50 | 106±n/a nM | ||
Citation | Chowdhury, S; Dehnhardt, CM; Focken, T; Grimwood, ME; Hemeon, IW; Jia, Q; Ortwine, DF; Safina, B; Sun, S; Sutherlin, DP; Zenova, AY N-substituted benzamides and methods of use thereof US Patent US9771376 Publication Date 9/26/2017 | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium channel protein type 9 subunit alpha | |||
Name: | Sodium channel protein type 9 subunit alpha | ||
Synonyms: | NENA | Neuroendocrine sodium channel | Peripheral sodium channel 1 | SCN9A | SCN9A_HUMAN | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
Type: | Protein | ||
Mol. Mass.: | 226375.97 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15858 | ||
Residue: | 1988 | ||
Sequence: |
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BDBM342434 | |||
n/a | |||
Name | BDBM342434 | ||
Synonyms: | 5-chloro-4-(cyclohexylmethoxy)-2-fluoro-N-(methylsulfonyl)benzamide | US9771376, Example 21 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H23ClN2O4S | ||
Mol. Mass. | 410.915 | ||
SMILES | CS(=O)(=O)NC(=O)c1cnc(OCC23CC4CC5(CC(C5)(C4)C2)C3)c(Cl)c1 |TLB:16:17:22:15.21.14,14:13:18:20,THB:16:15:22:18.23.17,20:17:22:15.21.14,12:13:18:20,(6.38,2.1,;5.61,3.43,;6.95,4.2,;4.84,4.77,;4.28,2.66,;2.94,3.43,;2.94,4.97,;1.61,2.66,;.28,3.43,;-1.06,2.66,;-1.06,1.12,;-2.39,.35,;-3.93,.35,;-4.7,-.98,;-6.17,-.57,;-6.94,-1.9,;-6.95,-3.44,;-5.46,-3.86,;-4.37,-4.95,;-4.39,-3.43,;-4.4,-4.97,;-5.87,-3.02,;-3.61,-2.07,;-4.7,-2.52,;.28,.35,;.28,-1.19,;1.61,1.12,)| | ||
Structure |