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TargetRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
LigandBDBM14396
Substrate/CompetitorBDBM14391
Meas. Tech.PDE Enzyme Inhibitor Assays
pH7.4±n/a
Temperature303.15±n/a K
IC50 1.4±n/a nM
CommentscGMP in a 3:1 ratio unlabeled to 3H-labeled at a concentration 1/3Km, such that IC50 = Ki.
Citation Allerton, CMBarber, CGBeaumont, KCBrown, DGCole, SMEllis, DLane, CAMaw, GNMount, NMRawson, DJRobinson, CMStreet, SDSummerhill, NW A novel series of potent and selective PDE5 inhibitors with potential for high and dose-independent oral bioavailability. J Med Chem49:3581-94 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Name:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Synonyms:CNRG_CANLF | GMP-PDE gamma | PDE6G | PDEG | Phosphodiesterase Type 6 (PDE6) | Retinal rod rhodopsin-sensitive cGMP 3 ,5 -cyclic phosphodiesterase subunit gamma
Type:Enzyme
Mol. Mass.:9656.12
Organism:Canis lupus familiaris (Dog)
Description:n/a
Residue:87
Sequence:
MNLEPPKAEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGL
GTDITVICPWEAFNHLELHELAQYGII
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BDBM14396
BDBM14391
NameBDBM14396
Synonyms:5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one | Sildenafil 5-methyl ketone analogue 56
TypeSmall organic molecule
Emp. Form.C23H29N5O4
Mol. Mass.439.5075
SMILESCCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)C(=O)CN1CCOCC1
Structure
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