| Reaction Details |
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 | Report a problem with these data |
| Target | Urokinase-type plasminogen activator [179-431,I214M,N322A,S371A] |
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| Ligand | BDBM14150 |
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| Substrate/Competitor | BDBM14484 |
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| Meas. Tech. | Enzyme Assay and Determination of the Inhibition Constants |
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| Ki | 1600±n/a nM |
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| Citation |  Katz, BA; Luong, C; Ho, JD; Somoza, JR; Gjerstad, E; Tang, J; Williams, SR; Verner, E; Mackman, RL; Young, WB; Sprengeler, PA; Chan, H; Mortara, K; Janc, JW; McGrath, ME Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA). J Mol Biol344:527-47 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Urokinase-type plasminogen activator [179-431,I214M,N322A,S371A] |
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| Name: | Urokinase-type plasminogen activator [179-431,I214M,N322A,S371A] |
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| Synonyms: | LMW uPA | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase (uPA) Mutant (S190A) | deglycosylated (N145A) LMW uPA Mutant S190A |
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| Type: | Enzyme |
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| Mol. Mass.: | 28389.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Mutagenically deglycosylated (N145A) low molecular mass urokinase (S190A), referred to as Ala190 uPA. |
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| Residue: | 253 |
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| Sequence: | IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFIDYPKKEDYIVY
LGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTI
CLPSMYNDPQFGTSCEITGFGKEASTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTK
MLCAADPQWKTDACQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPW
IRSHTKEENGLAL
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| BDBM14150 |
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| BDBM14484 |
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| Name | BDBM14150 |
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| Synonyms: | APC-11417 | CA-12 | CRA-11417 | {amino[6-fluoro-2-(2-hydroxy-3-phenylphenyl)-1H-indol-5-yl]methylidene}azanium |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17FN3O |
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| Mol. Mass. | 346.377 |
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| SMILES | NC(=[NH2+])c1cc2cc([nH]c2cc1F)-c1cccc(-c2ccccc2)c1O |
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| Structure | 
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