Reaction Details |
| Report a problem with these data |
Target | Coagulation factor VII |
---|
Ligand | BDBM14514 |
---|
Substrate/Competitor | BDBM14496 |
---|
Meas. Tech. | TF-VIIa Assay |
---|
pH | 8±n/a |
---|
Temperature | 295.15±n/a K |
---|
IC50 | 200±n/a nM |
---|
Citation | Parlow, JJ; Case, BL; Dice, TA; Fenton, RL; Hayes, MJ; Jones, DE; Neumann, WL; Wood, RS; Lachance, RM; Girard, TJ; Nicholson, NS; Clare, M; Stegeman, RA; Stevens, AM; Stallings, WC; Kurumbail, RG; South, MS Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex. J Med Chem46:4050-62 (2003) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
Coagulation factor VII |
---|
Name: | Coagulation factor VII |
Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
Type: | Enzyme |
Mol. Mass.: | 51599.89 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 466 |
Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
|
|
|
BDBM14514 |
---|
BDBM14496 |
---|
Name | BDBM14514 |
Synonyms: | (2R)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-(pyridin-3-yl)ethyl]-3-phenyl-2-(phenylmethane)sulfonamidopropanamide | CHEMBL78053 | Ketothiazole inhibitor 1 |
Type | Small organic molecule |
Emp. Form. | C33H38N8O5S2 |
Mol. Mass. | 690.835 |
SMILES | [#7]\[#6](-[#7])=[#7]/[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1cccnc1)-[#7]-[#6](=O)-[#6@@H](-[#6]-c1ccccc1)-[#7]S(=O)(=O)[#6]-c1ccccc1)-[#6](=O)-c1nccs1 |r| |
Structure |
|