| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 4 |
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| Ligand | BDBM344298 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 50.0±n/a nM |
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| Citation |  Dominguez, C; Muñoz-Sanjuán, I; Maillard, M; Raphy, G; Haughan, AF; Luckhurst, CA; Jarvis, RE; Bürli, RW; Breccia, P; Wishart, G; Hughes, SJ; Allen, DR; Penrose, SD Histone deacetylase inhibitors and compositions and methods of use thereof US Patent US9783488 Publication Date 10/10/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 4 |
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| Name: | Histone deacetylase 4 |
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| Synonyms: | Cereblon/Histone deacetylase 4 | HD4 | HDAC4 | HDAC4_HUMAN | Histone acetylase 4(HDAC4) | Human HDAC4 | KIAA0288 |
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| Type: | Enzyme |
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| Mol. Mass.: | 119049.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P56524 |
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| Residue: | 1084 |
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| Sequence: | MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP
VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA
MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL
NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP
LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP
SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA
TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL
EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL
VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY
LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ
RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT
LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT
LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE
LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD
VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP
PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL
MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV
MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE
EPPL
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| BDBM344298 |
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| n/a |
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| Name | BDBM344298 |
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| Synonyms: | (1R*,3R*)-1-(3-Fluoro-2- methylphenyl)-N-hydroxy- 3- phenylcyclopentanecarboxamide | US9783488, Example 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20FNO2 |
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| Mol. Mass. | 313.366 |
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| SMILES | Cc1c(F)cccc1[C@]1(CC[C@H](C1)c1ccccc1)C(=O)NO |r| |
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| Structure | 
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