| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM345099 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kallikrein Assay |
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| IC50 | 17.6±n/a nM |
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| Citation |  Liu, W; Edmondson, SD; Guo, Z; Mertz, E; Ogawa, AK; So, S; Sun, W; Brockunier, LL; Ali, A; Kuang, R; Wu, H Factor Xla inhibitors US Patent US9783530 Publication Date 10/10/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM345099 |
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| n/a |
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| Name | BDBM345099 |
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| Synonyms: | 4-[(2-{5-[5-chloro-2-(1H- tetrazol-1-yl)phenyl]-1- oxidopyridin-2-yl}-3- cyclopropylpropanoyl) amino]-2-fluorobenzoic acid | US9783530, 44 | US9783530, 45 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20ClFN6O4 |
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| Mol. Mass. | 522.916 |
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| SMILES | OC(=O)c1ccc(NC(=O)C(CC2CC2)c2ccc(c[n+]2[O-])-c2cc(Cl)ccc2-n2cnnn2)cc1F |
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| Structure | 
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