| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM14699 |
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| Substrate/Competitor | BDBM14700 |
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| Meas. Tech. | DHODH Inhibition Assay |
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| pH | 8±n/a |
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| Temperature | 298.15±n/a K |
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| Ki | 20±n/a nM |
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| IC50 | 160±50 nM |
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| Km | 13400±n/a nM |
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| Citation |  Heikkila, T; Ramsey, C; Davies, M; Galtier, C; Stead, AM; Johnson, AP; Fishwick, CW; Boa, AN; McConkey, GA Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. J Med Chem50:186-91 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | PYRD_PLAF7 |
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| Type: | Enzyme |
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| Mol. Mass.: | 65581.88 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | Q08210 |
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| Residue: | 569 |
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| Sequence: | MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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| BDBM14699 |
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| BDBM14700 |
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| Name | BDBM14699 |
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| Synonyms: | 1,3-diethyl 2-({8-thiatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaen-4-ylamino}methylidene)propanedioate | 2-(Dibenzothiophen-2-ylaminomethylene)-malonic acid diethyl ester | tricyclic compound 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19NO4S |
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| Mol. Mass. | 369.434 |
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| SMILES | CCOC(=O)C(C=Nc1ccc2sc3ccccc3c2c1)C(=O)OCC |w:7.7| |
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| Structure | 
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