Reaction Details |
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Target | Monocarboxylate transporter 4 |
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Ligand | BDBM345265 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Lactate Transport in MCT4-Expressing MDA-MB-453 Breast Cancer Cells |
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IC50 | 45.0±n/a nM |
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Citation | Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Monocarboxylate transporter 4 |
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Name: | Monocarboxylate transporter 4 |
Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 |
Type: | PROTEIN |
Mol. Mass.: | 49474.36 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_104604 |
Residue: | 465 |
Sequence: | MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
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BDBM345265 |
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n/a |
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Name | BDBM345265 |
Synonyms: | 2-[[1-[(2-Chlorophenyl)methyl]-5-(m- tolyl)pyrazol-3-yl]methoxy]-2-methyl- propanoic acid 1H NMR (CDCl3, 400 MHz) $#948; 1.58 (s, 6H), 2.35 (s, 3H), 4.61 (s, 2H), 5.42 (s, 2H), 6.39 (s, 1H), 6.75-6.84 (m, 1H), 7.00- 7.12 (m, 2H), 7.18-7.29 (4H), 7.29-7.38 (m, 1H). | US10202350, Example 11 | US10214492, Example 11 | US11292767, Example 11 | US11724989, Example 11 |
Type | Small organic molecule |
Emp. Form. | C22H23ClN2O3 |
Mol. Mass. | 398.883 |
SMILES | Cc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Cl |
Structure |
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