Reaction Details | |||
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Target | Monocarboxylate transporter 4 | ||
Ligand | BDBM345267 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Lactate Transport in MCT4-Expressing MDA-MB-453 Breast Cancer Cells | ||
IC50 | 20.0±n/a nM | ||
Citation | Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Monocarboxylate transporter 4 | |||
Name: | Monocarboxylate transporter 4 | ||
Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 49474.36 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_104604 | ||
Residue: | 465 | ||
Sequence: |
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BDBM345267 | |||
n/a | |||
Name | BDBM345267 | ||
Synonyms: | 2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (trifluoromethyl)phenyl]pyrazol-3- yl]methoxy]-2-methyl-propanoic acid 1H NMR (CDCl3, 400 MHz) $#948; 1.58 (s, 6H), 4.62 (s, 2H), 5.41 (s, 2H), 6.46 (s, 1H), 6.80-6.88 (m, 1H), 7.17-7.24 (m, 2H), 7.29-7.38 (m, 1H), 7.39-7.47 (m, 1H), 7.49-7.54 (m, 2H), 7.59-7.68 (m, 1H). | US10202350, Example 13 | US10214492, Example 13 | US11292767, Example 13 | US11724989, Example 13 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H20ClF3N2O3 | ||
Mol. Mass. | 452.854 | ||
SMILES | CC(C)(OCc1cc(-c2cccc(c2)C(F)(F)F)n(Cc2ccccc2Cl)n1)C(O)=O | ||
Structure |