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TargetMonocarboxylate transporter 4
LigandBDBM345267
Substrate/Competitorn/a
Meas. Tech.Lactate Transport in MCT4-Expressing MDA-MB-453 Breast Cancer Cells
IC50 20.0±n/a nM
Citation Parnell, KMMcCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019
More Info.:Get all data from this article,  Assay Method
 
Monocarboxylate transporter 4
Name:Monocarboxylate transporter 4
Synonyms:MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3
Type:PROTEIN
Mol. Mass.:49474.36
Organism:Homo sapiens (Human)
Description:ChEMBL_104604
Residue:465
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM345267
n/a
NameBDBM345267
Synonyms:2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (trifluoromethyl)phenyl]pyrazol-3- yl]methoxy]-2-methyl-propanoic acid 1H NMR (CDCl3, 400 MHz) $#948; 1.58 (s, 6H), 4.62 (s, 2H), 5.41 (s, 2H), 6.46 (s, 1H), 6.80-6.88 (m, 1H), 7.17-7.24 (m, 2H), 7.29-7.38 (m, 1H), 7.39-7.47 (m, 1H), 7.49-7.54 (m, 2H), 7.59-7.68 (m, 1H). | US10202350, Example 13 | US10214492, Example 13 | US11292767, Example 13 | US11724989, Example 13
TypeSmall organic molecule
Emp. Form.C22H20ClF3N2O3
Mol. Mass.452.854
SMILESCC(C)(OCc1cc(-c2cccc(c2)C(F)(F)F)n(Cc2ccccc2Cl)n1)C(O)=O
Structure
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