Reaction Details | |||
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Target | Monocarboxylate transporter 4 | ||
Ligand | BDBM345283 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Assay 3: MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells | ||
IC50 | 3.70±n/a nM | ||
Citation | Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Monocarboxylate transporter 4 | |||
Name: | Monocarboxylate transporter 4 | ||
Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 49474.36 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_104604 | ||
Residue: | 465 | ||
Sequence: |
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BDBM345283 | |||
n/a | |||
Name | BDBM345283 | ||
Synonyms: | 2-[[1-[(2-Bromophenyl)methyl]-5-(3- isopropoxyphenyl)pyrazol-3-yl]methoxy]- 2-methyl-propanoic acid. 1HNMR (CDCl3): $#948; 1.21 (s, 3H), 1.23 (s, 3H), 4.28-4.32 (m, 1H), 4.62 (s, 2H), 5.39 (s, 2H).6.42 (s, 1H), 6.71-6.74 (m, 2H), 6.82- 6.89 (m, 2H), 7.11-7.15 (m, 1H), 7.22- 7.27 (m, 2H), 7.51-7.54 (m, 1H). | US10202350, Example 29 | US10214492, Example 29 | US11292767, Example 29 | US11724989, Example 29 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H27BrN2O4 | ||
Mol. Mass. | 487.386 | ||
SMILES | CC(C)Oc1cccc(c1)-c1cc(COC(C)(C)C(O)=O)nn1Cc1ccccc1Br | ||
Structure |