| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Monocarboxylate transporter 4 |
|---|
| Ligand | BDBM345291 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Assay 3: MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells |
|---|
| IC50 | 7.60±n/a nM |
|---|
| Citation |  Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Monocarboxylate transporter 4 |
|---|
| Name: | Monocarboxylate transporter 4 |
|---|
| Synonyms: | MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 49474.36 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_104604 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
|
|
|
|---|
| BDBM345291 |
|---|
| n/a |
|---|
| Name | BDBM345291 |
|---|
| Synonyms: | 2-[[1-[(2-Chlorophenyl)methyl]-5-[3- (cyclobutoxy)phenyl]pyrazol-3- yl]methoxy]-2-methyl-propanoic acid. 1HNMR (CDCl3): $#948; 1.49-1.61 (m, 7H), m1.75-1.82 (m 1H), 2.01-2.11 (m 2H), 2.17-2.24 (m 2H), 4.37-4.45 (m 1H), 4.62 (s, 2H), 5.42 (s, 2H), 6.39 (s, 1H), 6.64 (s, 1H), 6.75-6.86 (m, 3H), 7.19-7.35 (m 4H). | US10202350, Example 37 | US10214492, Example 37 | US11292767, Example 37 | US11724989, Example 37 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H27ClN2O4 |
|---|
| Mol. Mass. | 454.946 |
|---|
| SMILES | CC(C)(OCc1cc(-c2cccc(OC3CCC3)c2)n(Cc2ccccc2Cl)n1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
