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TargetMonocarboxylate transporter 4
LigandBDBM345315
Substrate/Competitorn/a
Meas. Tech.Assay 3: MCT4-Mediated Lactate Transport in MDA-MB-231 Breast Cancer Cells
IC50 3.10±n/a nM
Citation Parnell, KMMcCall, J MCT4 inhibitors for treating disease US Patent US10202350 Publication Date 2/12/2019
More Info.:Get all data from this article,  Assay Method
 
Monocarboxylate transporter 4
Name:Monocarboxylate transporter 4
Synonyms:MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3
Type:PROTEIN
Mol. Mass.:49474.36
Organism:Homo sapiens (Human)
Description:ChEMBL_104604
Residue:465
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDT
AWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGV
ITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGF
LILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVL
GLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSF
SMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVL
LMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPE
VAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM345315
n/a
NameBDBM345315
Synonyms:2-([1-[(2-methoxyphenyl)methyl]-5-[3-(2- methylpropoxy)phenyl]-1H-pyrazol-3- yl]methoxy)-2-methylpropanoic acid LC-MS (ES, m/z): 453 1H-NMR (400 MHz, MeOD) $#948; 0.97 (6 H, d), 1.53 (6 H, s), 1.97 (1 H, dp), 3.48 (2 H, d), 3.78 (3 H, s), 4.58 (2 H, s), 5.31 (2 H, s), 6.52 (1 H, s), 6.67-6.74 (1 H, m), 6.76- 6.82 (1 H, m), 6.85-7.00 (4 H, m), 7.22- 7.33 (2 H, m). | US10202350, Example 61 | US10214492, Example 61 | US11292767, Example 61 | US11724989, Example 61
TypeSmall organic molecule
Emp. Form.C26H32N2O5
Mol. Mass.452.5427
SMILESCOc1ccccc1Cn1nc(COC(C)(C)C(O)=O)cc1-c1cccc(OCC(C)C)c1
Structure
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