| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [42-168] |
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| Ligand | BDBM50365262 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Enzyme Inhibition Assay-BRD4 Inhibition |
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| IC50 | <500±n/a nM |
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| Citation |  Bennett, MJ; Betancort, JM; Boloor, A; Kanouni, T; Stafford, JA; Veal, JM; Wallace, MB Therapeutic compounds US Patent US10202360 Publication Date 2/12/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 4 [42-168] |
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| Name: | Bromodomain-containing protein 4 [42-168] |
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| Synonyms: | BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 15054.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60885[42-168] |
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| Residue: | 127 |
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| Sequence: | STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKII
KTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTEE
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| BDBM50365262 |
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| n/a |
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| Name | BDBM50365262 |
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| Synonyms: | (+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10124009, Compound (S)-JQ1 | US10202360, Example JQ-1 | US10308662, Compound JQ-1 | US10407441, Compound (S)-JQ1 | US10617680, Example JQ-1 | US10881668, Compound JQ1 | US10925881, Name (S)-JQ1 | US11020380, Example JQ-1 | US11078188, Example (+)-JQ1 | US11279703, TABLE 6.180 | US11427593, Compound JQ1 | US11466034, Example (+)-JQ1 | US9320741, (S)-JQ1 | US9695172, JQ1 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25ClN4O2S |
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| Mol. Mass. | 456.988 |
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| SMILES | Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14| |
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| Structure | 
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