| Reaction Details |
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 | Report a problem with these data |
| Target | Intermediate conductance calcium-activated potassium channel protein 4 |
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| Ligand | BDBM205030 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.3±n/a |
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| IC50 | 16.0±0 nM |
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| Comments | extracted |
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| Citation |  Demnitz, J; Jorgensen, S Tetrazole derivatives and their use as potassium channel modulators US Patent US9556132 Publication Date 1/31/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Intermediate conductance calcium-activated potassium channel protein 4 |
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| Name: | Intermediate conductance calcium-activated potassium channel protein 4 |
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| Synonyms: | IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47723.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1361891 |
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| Residue: | 427 |
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| Sequence: | MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
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| BDBM205030 |
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| n/a |
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| Name | BDBM205030 |
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| Synonyms: | US9556132, 7 | process for preparing 2-(2-{2-[1-(2-fluorophenyl)-1h-1,2,3,4-tetrazol-5-yl]phenyl}phenoxy)acetonitrile |
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| Type | Small organic molecule |
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| Emp. Form. | C21H14FN5O |
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| Mol. Mass. | 371.3672 |
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| SMILES | Fc1ccccc1-n1nnnc1-c1ccccc1-c1ccccc1OCC#N |
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| Structure | 
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