Reaction Details |
| Report a problem with these data |
Target | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] |
---|
Ligand | BDBM14775 |
---|
Substrate/Competitor | BDBM10851 |
---|
Meas. Tech. | Phosphodiesterase (PDE) Inhibition Assay |
---|
IC50 | 11000±n/a nM |
---|
Citation | Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] |
---|
Name: | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] |
Synonyms: | CGI-PDE B | CGIP1 | CGIPDE1 | Cyclic GMP-inhibited phosphodiesterase B | PDE3B | PDE3B_HUMAN | cGMP-inhibited 3',5'-cyclic phosphodiesterase B (aa 650-1084) | cGMP-inhibited 3',5'-cyclic phosphodiesterase B [650-1084] | cGMP-inhibited 3,5-cyclic phosphodiesterase B |
Type: | Enzyme |
Mol. Mass.: | 49825.61 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant catalytic domain (Q650-A1084) of human PDE3B. |
Residue: | 435 |
Sequence: | QTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGL
LEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGT
GNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRT
NAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEA
ILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHL
KWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLL
PGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENH
KIWKEIVEEEEKCKA
|
|
|
BDBM14775 |
---|
BDBM10851 |
---|
Name | BDBM14775 |
Synonyms: | 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide | 3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxy-benzamide | CHEMBL42126 | Cpodpmb | Piclamilast | RPR-73401 |
Type | Small organic molecule |
Emp. Form. | C18H18Cl2N2O3 |
Mol. Mass. | 381.253 |
SMILES | COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl |
Structure |
|