Reaction Details |
| Report a problem with these data |
Target | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] |
---|
Ligand | BDBM14777 |
---|
Substrate/Competitor | BDBM10851 |
---|
Meas. Tech. | Phosphodiesterase (PDE) Inhibition Assay |
---|
IC50 | 280000±n/a nM |
---|
Citation | Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] |
---|
Name: | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [650-1084] |
Synonyms: | CGI-PDE B | CGIP1 | CGIPDE1 | Cyclic GMP-inhibited phosphodiesterase B | PDE3B | PDE3B_HUMAN | cGMP-inhibited 3',5'-cyclic phosphodiesterase B (aa 650-1084) | cGMP-inhibited 3',5'-cyclic phosphodiesterase B [650-1084] | cGMP-inhibited 3,5-cyclic phosphodiesterase B |
Type: | Enzyme |
Mol. Mass.: | 49825.61 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant catalytic domain (Q650-A1084) of human PDE3B. |
Residue: | 435 |
Sequence: | QTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGL
LEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGT
GNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRT
NAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEA
ILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHL
KWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLL
PGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENH
KIWKEIVEEEEKCKA
|
|
|
BDBM14777 |
---|
BDBM10851 |
---|
Name | BDBM14777 |
Synonyms: | (2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11(16),12,14-tetraene-4,7-dione | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1,2,1,6]pyrido[3,4-b]indole-1,4-dione | CHEMBL779 | Cialis | GF 196960 | Tadalafil |
Type | Small organic molecule |
Emp. Form. | C22H19N3O4 |
Mol. Mass. | 389.404 |
SMILES | [H][C@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CN(C)C2=O)c1ccc2OCOc2c1 |r| |
Structure |
|