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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)
LigandBDBM14390
Substrate/CompetitorBDBM10851
Meas. Tech.Phosphodiesterase (PDE) Inhibition Assay
IC50 14000±n/a nM
Citation Card, GLEngland, BPSuzuki, YFong, DPowell, BLee, BLuu, CTabrizizad, MGillette, SIbrahim, PNArtis, DRBollag, GMilburn, MVKim, SHSchlessinger, JZhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)
Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)
Synonyms:DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase Type 4 (PDE4D) | cAMP-specific 3,5-cyclic phosphodiesterase 4D
Type:Enzyme Catalytic Domain
Mol. Mass.:40034.37
Organism:Homo sapiens (Human)
Description:RECOMBINANT CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D.
Residue:349
Sequence:
MGSSHHHHHHSSGLVPRGSHMTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT
IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV
FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE
NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS
DRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS
VEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM14390
BDBM10851
NameBDBM14390
Synonyms:5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one | 5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one | CHEMBL192 | SILDENAFIL CITRATE | Sildenafil | Sildenafil# | US11155558, Compound sildenafil | US11242347, Compound sildenafil | Viagra
TypeSmall organic molecule
Emp. Form.C22H30N6O4S
Mol. Mass.474.576
SMILESCCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Structure
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