Ki Summary

Reaction Details

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Target

cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450]

Ligand

BDBM14773

Substrate/Competitor

BDBM10851

Meas. Tech.

Phosphodiesterase (PDE) Inhibition Assay

IC50

44000±n/a nM

Citation

Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450]

Name:

cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450]

Synonyms:

PDE7B | PDE7B_HUMAN | Phosphodiesterase Type 7 (PDE7B) | cAMP-specific 3,5-cyclic phosphodiesterase 7B

Type:

Enzyme Catalytic Domain

Mol. Mass.:

41494.16

Organism:

Homo sapiens (Human)

Description:

Recombinant catalytic domain (Q91-P450) of human PDE7B.

Residue:

360

Sequence:

QAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKL
DMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAA
AAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQD
IEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRI
WEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWA
HFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP

BDBM14773

BDBM10851

Name

BDBM14773

Synonyms:

4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)cyclohexane-1-carboxylic acid | 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid | Ariflo | Cilomilast | SB207499

Type

Small organic molecule

Emp. Form.

C20H25NO4

Mol. Mass.

343.4168

SMILES

COc1ccc(cc1OC1CCCC1)C1(CCC(CC1)C(O)=O)C#N |(1.4,-2.1,;1.4,-.56,;.07,.21,;-1.27,-.56,;-2.6,.21,;-2.6,1.75,;-1.27,2.52,;.07,1.75,;1.4,2.52,;1.4,4.06,;2.65,4.96,;2.17,6.43,;.63,6.43,;.15,4.96,;-3.93,2.52,;-4.44,3.97,;-5.95,4.26,;-6.96,3.1,;-6.46,1.65,;-4.94,1.35,;-8.47,3.39,;-9.48,2.23,;-8.97,4.85,;-3.16,3.85,;-2.39,5.18,)|

Structure