Ki Summary

Reaction Details

Report a problem with these data

Target

cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450]

Ligand

BDBM14390

Substrate/Competitor

BDBM10851

Meas. Tech.

Phosphodiesterase (PDE) Inhibition Assay

IC50

78000±n/a nM

Citation

Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450]

Name:

cAMP-specific 3',5'-cyclic phosphodiesterase 7B [91-450]

Synonyms:

PDE7B | PDE7B_HUMAN | Phosphodiesterase Type 7 (PDE7B) | cAMP-specific 3,5-cyclic phosphodiesterase 7B

Type:

Enzyme Catalytic Domain

Mol. Mass.:

41494.16

Organism:

Homo sapiens (Human)

Description:

Recombinant catalytic domain (Q91-P450) of human PDE7B.

Residue:

360

Sequence:

QAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKL
DMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAA
AAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQD
IEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRI
WEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWA
HFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP

BDBM14390

BDBM10851

Name

BDBM14390

Synonyms:

5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one | 5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one | CHEMBL192 | SILDENAFIL CITRATE | Sildenafil | Sildenafil# | US11155558, Compound sildenafil | US11242347, Compound sildenafil | Viagra

Type

Small organic molecule

Emp. Form.

C22H30N6O4S

Mol. Mass.

474.576

SMILES

CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1

Structure