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TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593]
LigandBDBM14774
Substrate/CompetitorBDBM14391
IC50>200000±n/a nM
Citation Card, GLEngland, BPSuzuki, YFong, DPowell, BLee, BLuu, CTabrizizad, MGillette, SIbrahim, PNArtis, DRBollag, GMilburn, MVKim, SHSchlessinger, JZhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593]
Name:High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593]
Synonyms:High-affinity cGMP-specific 3,5-cyclic phosphodiesterase 9A | PDE9A | PDE9A_HUMAN | Phosphodiesterase Type 9 (PDE9A)
Type:Enzyme Catalytic Domain
Mol. Mass.:43183.20
Organism:Homo sapiens (Human)
Description:Recombinant catalytic domain (S226-A593) of human PDE9A.
Residue:368
Sequence:
SFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLV
RDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILIL
MTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIP
PDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISN
EVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMF
ETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDV
KNSEGDCA
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  Blast E-value cutoff:
BDBM14774
BDBM14391
NameBDBM14774
Synonyms:3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide | CHEMBL193240 | DAXAS | ROF | Roflumilast
TypeSmall organic molecule
Emp. Form.C17H14Cl2F2N2O3
Mol. Mass.403.207
SMILESFC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl
Structure
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