Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetIsoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489]
LigandBDBM14775
Substrate/CompetitorBDBM10851
Meas. Tech.Phosphodiesterase (PDE) Inhibition Assay
IC50 1600±n/a nM
Citation Card, GL; England, BP; Suzuki, Y; Fong, D; Powell, B; Lee, B; Luu, C; Tabrizizad, M; Gillette, S; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY Structural basis for the activity of drugs that inhibit phosphodiesterases. Structure12:2233-47 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489]
Name:Isoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489]
Synonyms:Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) [135-489] | PDE11A | PDE11_HUMAN | Phosphodiesterase 11A isoform 4 | Phosphodiesterase Type 11 (PDE11A)
Type:Enzyme Catalytic Domain
Mol. Mass.:40811.01
Organism:Homo sapiens (Human)
Description:Q9HCR9-4 aa 135-489
Residue:355
Sequence:
DVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQ
KFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVI
VGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSS
KEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLG
AVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICM
PLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM14775
BDBM10851
NameBDBM14775
Synonyms:3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide | 3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxy-benzamide | CHEMBL42126 | Cpodpmb | Piclamilast | RPR-73401
TypeSmall organic molecule
Emp. Form.C18H18Cl2N2O3
Mol. Mass.381.253
SMILESCOc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: