| Reaction Details |
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 | Report a problem with these data |
| Target | Atypical chemokine receptor 3 |
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| Ligand | BDBM345977 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assay |
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| EC50 | 1.000±n/a nM |
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| Citation |  Guerry, P; Lehembre, F; Pothier, J; Siendt, H CXCR7 receptor modulators US Patent US10202368 Publication Date 2/12/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Atypical chemokine receptor 3 |
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| Name: | Atypical chemokine receptor 3 |
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| Synonyms: | ACKR3 | ACKR3_HUMAN | C-X-C chemokine receptor type 7 | C-X-C chemokine receptor type 7 (CXCR7) | CMKOR1 | CXC-R7 | CXCR-7 | CXCR7 | Chemokine orphan receptor 1 | G-protein coupled receptor 159 | G-protein coupled receptor RDC1 homolog | GPR159 | RDC-1 | RDC1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41498.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25106 |
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| Residue: | 362 |
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| Sequence: | MDLHLFDYSEPGNFSDISWPCNSSDCIVVDTVMCPNMPNKSVLLYTLSFIYIFIFVIGMI
ANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVT
HLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDT
YYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAIS
ASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVT
QCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQS
TK
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| BDBM345977 |
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| n/a |
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| Name | BDBM345977 |
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| Synonyms: | 2-(4-Cyclopropylmethyl-1-methyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-9-ylamino)-N-(2-isopropylamino-ethyl)-N-(2-trifluoromethyl-benzyl)-acetamide | US10202368, Example 52 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H40F3N5O |
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| Mol. Mass. | 531.656 |
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| SMILES | CC(C)NCCN(Cc1ccccc1C(F)(F)F)C(=O)CNc1cccc2CN(CC3CC3)CCN(C)c12 |
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| Structure | 
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