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TargetP2X purinoceptor 3
LigandBDBM320216
Substrate/Competitorn/a
Meas. Tech.Intracellular Calcium Measurement to Assess Antagonist Activity
IC50 3.00±n/a nM
Citation Davenport, AJBräuer, NFischer, OMRotgeri, ARottmann, ANeagoe, INagel, JGodinho-Coelho, AKlar, J 1,3-thiazol-2-yl substituted benzamides US Patent US10202369 Publication Date 2/12/2019
More Info.:Get all data from this article,  Assay Method
 
P2X purinoceptor 3
Name:P2X purinoceptor 3
Synonyms:ATP receptor | Glucocorticoid receptor | P2RX3 | P2RX3_HUMAN | P2X purinoceptor 3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor | p2x3 + hsa
Type:Protein
Mol. Mass.:44292.02
Organism:Homo sapiens (Human)
Description:P56373
Residue:397
Sequence:
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS
QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE
VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
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  Blast E-value cutoff:
BDBM320216
n/a
NameBDBM320216
Synonyms:3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers | US10174016, Example 383 | US10202369, Example 384 | US10472354, Example 383
TypeSmall organic molecule
Emp. Form.C25H26F5N5O2S
Mol. Mass.555.563
SMILESC[C@@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F |r|
Structure
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