| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) |
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| Ligand | BDBM14778 |
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| Substrate/Competitor | BDBM10851 |
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| Meas. Tech. | Phosphodiesterase (PDE) Inhibition Assay |
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| IC50 | >200000±n/a nM |
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| Citation |  Card, GL; Blasdel, L; England, BP; Zhang, C; Suzuki, Y; Gillette, S; Fong, D; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design. Nat Biotechnol23:201-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) |
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| Synonyms: | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase Type 4 (PDE4D) | cAMP-specific 3,5-cyclic phosphodiesterase 4D |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40034.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | RECOMBINANT CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D. |
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| Residue: | 349 |
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| Sequence: | MGSSHHHHHHSSGLVPRGSHMTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT
IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV
FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE
NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS
DRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS
VEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQS
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| BDBM14778 |
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| BDBM10851 |
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| Name | BDBM14778 |
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| Synonyms: | 3,5-dimethyl-1H-pyrazole-4-carboxylic acid | Pyrazole carboxylic acid 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H8N2O2 |
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| Mol. Mass. | 140.1399 |
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| SMILES | Cc1n[nH]c(C)c1C(O)=O |
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| Structure | 
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