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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)
LigandBDBM14788
Substrate/CompetitorBDBM10851
Meas. Tech.Phosphodiesterase (PDE) Inhibition Assay
IC50 50000±n/a nM
Citation Card, GLBlasdel, LEngland, BPZhang, CSuzuki, YGillette, SFong, DIbrahim, PNArtis, DRBollag, GMilburn, MVKim, SHSchlessinger, JZhang, KY A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design. Nat Biotechnol23:201-7 (2005) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)
Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)
Synonyms:DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase Type 4 (PDE4D) | cAMP-specific 3,5-cyclic phosphodiesterase 4D
Type:Enzyme Catalytic Domain
Mol. Mass.:40034.37
Organism:Homo sapiens (Human)
Description:RECOMBINANT CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D.
Residue:349
Sequence:
MGSSHHHHHHSSGLVPRGSHMTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT
IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV
FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE
NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS
DRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS
VEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM14788
BDBM10851
NameBDBM14788
Synonyms:Pyrazole carboxylic ester 11 | ethyl 5-amino-1-{8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraen-3-yl}-1H-pyrazole-4-carboxylate
TypeSmall organic molecule
Emp. Form.C16H17N5O2S
Mol. Mass.343.403
SMILESCCOC(=O)c1cnn(c1N)-c1ncnc2sc3CCCCc3c12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: