Reaction Details |
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) |
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Ligand | BDBM14788 |
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Substrate/Competitor | BDBM10851 |
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Meas. Tech. | Phosphodiesterase (PDE) Inhibition Assay |
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IC50 | 50000±n/a nM |
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Citation | Card, GL; Blasdel, L; England, BP; Zhang, C; Suzuki, Y; Gillette, S; Fong, D; Ibrahim, PN; Artis, DR; Bollag, G; Milburn, MV; Kim, SH; Schlessinger, J; Zhang, KY A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design. Nat Biotechnol23:201-7 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) |
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Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M) |
Synonyms: | DPDE3 | PDE43 | PDE4D | PDE4D_HUMAN | Phosphodiesterase Type 4 (PDE4D) | cAMP-specific 3,5-cyclic phosphodiesterase 4D |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40034.37 |
Organism: | Homo sapiens (Human) |
Description: | RECOMBINANT CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D. |
Residue: | 349 |
Sequence: | MGSSHHHHHHSSGLVPRGSHMTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT
IFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAV
FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEE
NCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYS
DRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS
VEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQS
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BDBM14788 |
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BDBM10851 |
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Name | BDBM14788 |
Synonyms: | Pyrazole carboxylic ester 11 | ethyl 5-amino-1-{8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5-tetraen-3-yl}-1H-pyrazole-4-carboxylate |
Type | Small organic molecule |
Emp. Form. | C16H17N5O2S |
Mol. Mass. | 343.403 |
SMILES | CCOC(=O)c1cnn(c1N)-c1ncnc2sc3CCCCc3c12 |
Structure |
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