| Reaction Details |
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 | Report a problem with these data |
| Target | Protein Wnt-3a |
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| Ligand | BDBM346268 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dual-Cell beta-Catenin Reporter Assay |
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| IC50 | 0.890±n/a nM |
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| Citation |  Bhamra, I; Mathieson, M; Donoghue, C; Testar, R N-pyridinyl acetamide derivatives as Wnt signalling pathway inhibitors US Patent US10202375 Publication Date 2/12/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein Wnt-3a |
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| Name: | Protein Wnt-3a |
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| Synonyms: | WNT3A_MOUSE | Wnt-3a | Wnt3a | protein Wnt-3a precursor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39269.29 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_813156 |
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| Residue: | 352 |
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| Sequence: | MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYV
EIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGV
AFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDAR
SAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASE
MVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVS
SHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
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| BDBM346268 |
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| n/a |
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| Name | BDBM346268 |
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| Synonyms: | 2-[4-(2-methylpyrazol-3-yl)pyrrolo[2,3-b]pyridin-1-yl]-N-(5-pyrazin-2-yl-2-pyridyl)acetamide | US10202375, Example 31 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18N8O |
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| Mol. Mass. | 410.4313 |
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| SMILES | Cn1nccc1-c1ccnc2n(CC(=O)Nc3ccc(cn3)-c3cnccn3)ccc12 |
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| Structure | 
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