Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM14826 |
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Substrate/Competitor | Cdc25C peptide substrate |
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Meas. Tech. | Chk1 Enzymatic Assay |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 3±n/a nM |
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Citation | Wang, GT; Li, G; Mantei, RA; Chen, Z; Kovar, P; Gu, W; Xiao, Z; Zhang, H; Sham, HL; Sowin, T; Rosenberg, SH; Lin, NH 1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities. J Med Chem48:3118-21 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM14826 |
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Cdc25C peptide substrate |
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Name: | Cdc25C peptide substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 2519.88 |
Organism: | n/a |
Description: | Cdc25c peptide substrate contained a sequence of amino acid residues 204-225 of human phosphatase Cdc25C. |
Residue: | 22 |
Sequence: | |