Reaction Details |
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Target | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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Ligand | BDBM205457 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorometric Ub-AMC Hydrolysis Assay |
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pH | 7.5±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 6800±n/a nM |
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Comments | extracted |
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Citation | Ott, CA; Baljinnyam, B; Zakharov, AV; Jadhav, A; Simeonov, A; Zhuang, Z Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors. ACS Chem Biol12:2399-2407 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
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Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
Synonyms: | Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1 |
Type: | PROTEIN |
Mol. Mass.: | 24819.03 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_974327 |
Residue: | 223 |
Sequence: | MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHE
NFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE
TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMP
FPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
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BDBM205457 |
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n/a |
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Name | BDBM205457 |
Synonyms: | (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid | Celastrol | US11660306, Example Celastrol | acs.jmedchem.1c00409_ST.357 |
Type | Small organic molecule |
Emp. Form. | C29H38O4 |
Mol. Mass. | 450.6096 |
SMILES | CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O |r,c:1,6,11,t:9| |
Structure |
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