BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetG protein-activated inward rectifier potassium channel 4
LigandBDBM347047
Substrate/Competitorn/a
Meas. Tech.TBD
IC50 63.0±n/a nM
Citation Duncia JVGardner DSHynes JMacor JENair SKPaidi VRSantella JBSarkunam KSistla RKPolimera SRWu H Heteroaryl substituted aminopyridine compounds US Patent  US10202390 Publication Date 2/12/2019  Article
More Info.:Get all data from this article,  Assay Method
 
G protein-activated inward rectifier potassium channel 4
Name:G protein-activated inward rectifier potassium channel 4
Synonyms:CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | Potassium channel, inwardly rectifying subfamily J member 5
Type:PROTEIN
Mol. Mass.:47658.06
Organism:Homo sapiens (Human)
Description:ChEMBL_107914
Residue:419
Sequence:
MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM347047
n/a
NameBDBM347047
Synonyms:2-(7-chloroimidazo[1,2-b]pyridazin-3-yl)-N-isopropyl-5-(4-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-1-yl)pyridin-4-amine | US10202390, Example 2
TypeSmall organic molecule
Emp. Form.C22H24ClN7O
Mol. Mass.437.925
SMILESCC(C)Nc1cc(ncc1-c1cnn(c1)C1CCOCC1)-c1cnc2cc(Cl)cnn12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: