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TargetG protein-activated inward rectifier potassium channel 4
LigandBDBM347059
Substrate/Competitorn/a
Meas. Tech.TBD
IC50 9.00±n/a nM
Citation Duncia JVGardner DSHynes JMacor JENair SKPaidi VRSantella JBSarkunam KSistla RKPolimera SRWu H Heteroaryl substituted aminopyridine compounds US Patent  US10202390 Publication Date 2/12/2019  Article
More Info.:Get all data from this article,  Assay Method
 
G protein-activated inward rectifier potassium channel 4
Name:G protein-activated inward rectifier potassium channel 4
Synonyms:CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | Potassium channel, inwardly rectifying subfamily J member 5
Type:PROTEIN
Mol. Mass.:47658.06
Organism:Homo sapiens (Human)
Description:ChEMBL_107914
Residue:419
Sequence:
MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
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  Blast E-value cutoff:
BDBM347059
n/a
NameBDBM347059
Synonyms:US10202390, Example 14
TypeSmall organic molecule
Emp. Form.C21H23ClN8O2
Mol. Mass.454.913
SMILESCC(C)(O)CCc1cn(nn1)-c1cnc(cc1NC1COC1)-c1cnn2cc(Cl)cnc12
Structure
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