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TargetG protein-activated inward rectifier potassium channel 4
LigandBDBM347060
Substrate/Competitorn/a
Meas. Tech.TBD
IC50 6.00±n/a nM
Citation Duncia JVGardner DSHynes JMacor JENair SKPaidi VRSantella JBSarkunam KSistla RKPolimera SRWu H Heteroaryl substituted aminopyridine compounds US Patent  US10202390 Publication Date 2/12/2019  Article
More Info.:Get all data from this article,  Assay Method
 
G protein-activated inward rectifier potassium channel 4
Name:G protein-activated inward rectifier potassium channel 4
Synonyms:CIR | Cardiac inward rectifier | GIRK-4 | GIRK4 | Heart KATP channel | IRK-4 | Inward rectifier K(+) channel Kir3.4 | KATP-1 | KCNJ5 | Potassium channel, inwardly rectifying subfamily J member 5
Type:PROTEIN
Mol. Mass.:47658.06
Organism:Homo sapiens (Human)
Description:ChEMBL_107914
Residue:419
Sequence:
MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINQKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM347060
n/a
NameBDBM347060
Synonyms:3-(4-(isopropylamino)-5-(4-propyl-1H-1,2,3-triazol-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazine-7-carbonitrile | US10202390, Example 15
TypeSmall organic molecule
Emp. Form.C20H21N9
Mol. Mass.387.441
SMILESCCCc1cn(nn1)-c1cnc(cc1NC(C)C)-c1cnc2cc(cnn12)C#N
Structure
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