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TargetRAC-beta serine/threonine-protein kinase
LigandBDBM15022
Substrate/Competitorbiotinylated Akt peptide substrate
Meas. Tech.Akt Kinase Assay
pH7.5±n/a
Temperature295.15±n/a K
IC50 257±n/a nM
Citation Li, QWoods, KWThomas, SZhu, GDPackard, GFisher, JLi, TGong, JDinges, JSong, XAbrams, JLuo, YJohnson, EFShi, YLiu, XKlinghofer, VDes Jong, ROltersdorf, TStoll, VSJakob, CGRosenberg, SHGiranda, VL Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg Med Chem Lett16:2000-7 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
RAC-beta serine/threonine-protein kinase
Name:RAC-beta serine/threonine-protein kinase
Synonyms:AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta
Type:Enzyme
Mol. Mass.:55766.64
Organism:Homo sapiens (Human)
Description:n/a
Residue:481
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
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BDBM15022
biotinylated Akt peptide substrate
Name:biotinylated Akt peptide substrate
Synonyms:n/a
Type:Biotinylated Peptide
Mol. Mass.:3178.04
Organism:n/a
Description:Km=15 uM
Residue:28
Sequence:
biotin-Ahx-EELSPFRGRSRSAPPNLWAAQR