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TargetRAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D]
LigandBDBM2579
Substrate/Competitorbiotinylated Akt peptide substrate
Meas. Tech.Akt Kinase Assay
pH7.5±n/a
Temperature295.15±n/a K
IC50 1.5±n/a nM
Citation Li, QWoods, KWThomas, SZhu, GDPackard, GFisher, JLi, TGong, JDinges, JSong, XAbrams, JLuo, YJohnson, EFShi, YLiu, XKlinghofer, VDes Jong, ROltersdorf, TStoll, VSJakob, CGRosenberg, SHGiranda, VL Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg Med Chem Lett16:2000-7 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
RAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D]
Name:RAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D]
Synonyms:AKT1 | AKT1_HUMAN | C-AKT | PKB | Protein kinase B (Akt 1) | Protein kinase B alpha | RAC | RAC-PK-alpha
Type:Enzyme
Mol. Mass.:39513.28
Organism:Homo sapiens (Human)
Description:Recombinant His-tagged Akt1 (S378A, S381A, T450D, S473D; 139-480)
Residue:342
Sequence:
AKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTE
NRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIV
SALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAP
EVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKA
LLAGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYF
DEEFTAQMITIDPPDQDDSMECVDSERRPHFPQFDYSASGTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM2579
biotinylated Akt peptide substrate
Name:biotinylated Akt peptide substrate
Synonyms:n/a
Type:Biotinylated Peptide
Mol. Mass.:3178.04
Organism:n/a
Description:Km=15 uM
Residue:28
Sequence:
biotin-Ahx-EELSPFRGRSRSAPPNLWAAQR