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TargetcAMP-dependent protein kinase catalytic subunit alpha
LigandBDBM2579
Substrate/Competitorbiotinylated kemptide
Meas. Tech.PKA/PKC Kinase Assay
pH7.4±n/a
Temperature295.15±n/a K
IC50 3.6±n/a nM
Citation Li, QWoods, KWThomas, SZhu, GDPackard, GFisher, JLi, TGong, JDinges, JSong, XAbrams, JLuo, YJohnson, EFShi, YLiu, XKlinghofer, VDes Jong, ROltersdorf, TStoll, VSJakob, CGRosenberg, SHGiranda, VL Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg Med Chem Lett16:2000-7 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
cAMP-dependent protein kinase catalytic subunit alpha
Name:cAMP-dependent protein kinase catalytic subunit alpha
Synonyms:KAPCA_BOVIN | PKA C-alpha | PKC | PRKACA | Protein Kinase C | Protein Kinase C, bovine brain | cAMP-Dependent Protein Kinase (PKA) | cAMP-dependent Protein Kinase, bovine heart | cAMP-dependent protein kinase A | cAMP-dependent protein kinase alpha-catalytic subunit | cAMP-dependent protein kinase, alpha-catalytic subunit
Type:Enzyme Complex
Mol. Mass.:40627.77
Organism:Bos taurus (bovine)
Description:The PKA holoenzyme purified from bovine heart, exists as an inactive tetrameric complex, which consists of a regulatory dimer associated with two catalytic subunits. It requires cAMP to activate the enzymatic reaction.
Residue:351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML
VKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM2579
biotinylated kemptide
Name:biotinylated kemptide
Synonyms:n/a
Type:Biotinylated Peptide
Mol. Mass.:1353.09
Organism:n/a
Description:n/a
Residue:12
Sequence:
biotin-hx-LRRASLG