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TargetInterleukin-1 receptor-associated kinase 4
LigandBDBM50040793
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH7.2±n/a
Temperature298.15±n/a K
IC50 5.60±n/a nM
Commentsextracted
Citation Bhide, RSDuncia, JVHynes, JNair, SKPitts, WJKumar, SRGardner, DSMurugesan, NPaidi, VRSantella, JBSistla, RWu, H Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators US Patent US9546153 Publication Date 1/17/2017
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 4
Name:Interleukin-1 receptor-associated kinase 4
Synonyms:IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:Protein
Mol. Mass.:51519.08
Organism:Homo sapiens (Human)
Description:Q9NWZ3
Residue:460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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BDBM50040793
n/a
NameBDBM50040793
Synonyms:CHEMBL3352825 | US9546153, ex. 79
TypeSmall organic molecule
Emp. Form.C22H25FN6O2
Mol. Mass.424.4713
SMILESCC(C)(O)[C@H](F)CNC(=O)c1cnc(Nc2ccc3cnccc3n2)cc1NC1CC1 |r|
Structure
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