Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM15248 |
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Substrate/Competitor | Cdc25C peptide substrate |
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Meas. Tech. | Chk1 Enzymatic Assay |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 7±n/a nM |
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Citation | Tao, ZF; Wang, L; Stewart, KD; Chen, Z; Gu, W; Bui, MH; Merta, P; Zhang, H; Kovar, P; Johnson, E; Park, C; Judge, R; Rosenberg, S; Sowin, T; Lin, NH Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors. J Med Chem50:1514-27 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM15248 |
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Cdc25C peptide substrate |
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Name: | Cdc25C peptide substrate |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 2519.88 |
Organism: | n/a |
Description: | Cdc25c peptide substrate contained a sequence of amino acid residues 204-225 of human phosphatase Cdc25C. |
Residue: | 22 |
Sequence: | |