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TargetDihydroorotate dehydrogenase (quinone), mitochondrial
LigandBDBM15345
Substrate/CompetitorBDBM15346
Meas. Tech.DHODH Inhibition Assay
pH8±n/a
Temperature295.15±n/a K
IC50 50±10 nM
Citation Baldwin, JMichnoff, CHMalmquist, NAWhite, JRoth, MGRathod, PKPhillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Dihydroorotate dehydrogenase (quinone), mitochondrial
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase
Type:Enzyme
Mol. Mass.:65581.88
Organism:Plasmodium falciparum
Description:His6-tag DHODH was expressed in E. coli.
Residue:569
Sequence:
MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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BDBM15345
BDBM15346
NameBDBM15345
Synonyms:Asinex compound no. 1 | N-(2,4-dichlorophenyl)naphthalene-2-carboxamide
TypeSmall organic molecule
Emp. Form.C17H11Cl2NO
Mol. Mass.316.181
SMILESClc1ccc(NC(=O)c2ccc3ccccc3c2)c(Cl)c1
Structure
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