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TargetDihydroorotate dehydrogenase (quinone), mitochondrial
LigandBDBM15353
Substrate/CompetitorBDBM15346
Meas. Tech.DHODH Inhibition Assay
pH8±n/a
Temperature295.15±n/a K
IC50 80±20 nM
Citation Baldwin, JMichnoff, CHMalmquist, NAWhite, JRoth, MGRathod, PKPhillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Dihydroorotate dehydrogenase (quinone), mitochondrial
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase
Type:Enzyme
Mol. Mass.:65581.88
Organism:Plasmodium falciparum
Description:His6-tag DHODH was expressed in E. coli.
Residue:569
Sequence:
MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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BDBM15353
BDBM15346
NameBDBM15353
Synonyms:2-methyl-N-(naphthalen-1-yl)-3-nitrobenzamide | ChemBridge compound no. 8
TypeSmall organic molecule
Emp. Form.C18H14N2O3
Mol. Mass.306.3154
SMILESCc1c(cccc1[N+]([O-])=O)C(=O)Nc1cccc2ccccc12
Structure
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