Reaction Details |
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Target | Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] |
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Ligand | BDBM15345 |
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Substrate/Competitor | BDBM15346 |
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Meas. Tech. | DHODH Inhibition Assay |
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IC50 | >50000±n/a nM |
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Citation | Baldwin, J; Michnoff, CH; Malmquist, NA; White, J; Roth, MG; Rathod, PK; Phillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] |
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Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] |
Synonyms: | DHODH | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 39678.95 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHODH (amino acids 30 to 395) was cloned and expressed in E. coli. |
Residue: | 366 |
Sequence: | ATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRN
PVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFN
SHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLV
VNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIAS
VVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPI
IGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAI
GADHRR
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BDBM15345 |
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BDBM15346 |
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Name | BDBM15345 |
Synonyms: | Asinex compound no. 1 | N-(2,4-dichlorophenyl)naphthalene-2-carboxamide |
Type | Small organic molecule |
Emp. Form. | C17H11Cl2NO |
Mol. Mass. | 316.181 |
SMILES | Clc1ccc(NC(=O)c2ccc3ccccc3c2)c(Cl)c1 |
Structure |
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