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TargetDihydroorotate dehydrogenase (quinone), mitochondrial [30-395]
LigandBDBM15345
Substrate/CompetitorBDBM15346
Meas. Tech.DHODH Inhibition Assay
IC50>50000±n/a nM
Citation Baldwin, JMichnoff, CHMalmquist, NAWhite, JRoth, MGRathod, PKPhillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed]  Article
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Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395]
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395]
Synonyms:DHODH | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | PYRD_HUMAN
Type:Enzyme
Mol. Mass.:39678.95
Organism:Homo sapiens (Human)
Description:Recombinant human DHODH (amino acids 30 to 395) was cloned and expressed in E. coli.
Residue:366
Sequence:
ATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRN
PVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFN
SHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLV
VNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIAS
VVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPI
IGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAI
GADHRR
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BDBM15345
BDBM15346
NameBDBM15345
Synonyms:Asinex compound no. 1 | N-(2,4-dichlorophenyl)naphthalene-2-carboxamide
TypeSmall organic molecule
Emp. Form.C17H11Cl2NO
Mol. Mass.316.181
SMILESClc1ccc(NC(=O)c2ccc3ccccc3c2)c(Cl)c1
Structure
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